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Testing microalbuminuria improved detective ability of atrial fibrillation in hypertrophic cardiomyopathy patients

Volume 6, Issue 5, October 2021    |    PP. 365-380    |PDF (339 K)|    Pub. Date: September 5, 2021
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Author(s)
Xiaowei Jiang, Cardiology department, Xiangya hospital Central South University, Changsha, Hunan, China.
Min Yan, Internal medicine department, Changsha Medical University, Changsha, Hunan, China.

Abstract
Atrial fibrillation (AF) is common arrhythmia in hypertrophic cardiomyopathy (HCM) patients, and indicate badly prognosis. The aim of this study was to determine the value of testing microalbuminuria (MAU) to improve the detective ability of atrial fibrillation in hypertrophic cardiomyopathy patients. The study was retrospective study. 267 patients with HCM were included from June 2013 to June 2016. Urinary albumin excretion (UAE) was detected by immunoturbidimetry method. AF was defined according to Minnesota codes. Huge atrial dimension was defined as left atrial end-systolic dimension (LAESD)≥ 50mm. 267 patients were enrolled consecutively, 37(13.9%) had AF and 47(17.6%) had MAU. The levels of UAE increased with the prevalence of AF and huge atrial dimension. In multivariate logistic analysis, age, LAESD and UAE were significantly associated with AF. Compared with patients without MAU, patients with MAU were associated with increased risk of AF and huge atrial dimension. Combined measurements of age≥ 51.5 years, LAESD≥ 44.5mm and UAE≥ 22.6 mg/L indicated good predictive values in the presence of AF, with a specificity of 87.8% and a sensitivity of 86.5% in HCM patients. MAU might be a valuable index to evaluate the clinical status of AF in HCM patients. Testing MAU improve the detective ability of atrial fibrillation in hypertrophic cardiomyopathy patients.

Keywords
Albuminuria; Hypertrophic cardiomyopathy; Atrial fibrillation

Cite this paper
Xiaowei Jiang, Min Yan, Testing microalbuminuria improved detective ability of atrial fibrillation in hypertrophic cardiomyopathy patients, SCIREA Journal of Clinical Medicine. Vol. 6 , No. 5 , 2021 , pp. 365 - 380 .

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