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Characterization of Carbapenemases, Extended spectrum beta-lactamases, AmpC, Quinolone resistance and Aminoglycoside resistance determinants in Carbapenem -resistant Enterobacteriaceae clinical isolates in Mainland, China

Volume 6, Issue 3, June 2021    |    PP. 213-241    |PDF (1229 K)|    Pub. Date: June 8, 2021
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Author(s)
Huijuan Chen, College of Life Sciences & Bio-Engineering, Beijing University of Technology, Beijing 100124, China; Institute of Radiation Medicine, Beijing 100850, China.
Qiqi Liu, Institute of Radiation Medicine, Beijing 100850, China.
Gang Wu, College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Shengqi Wang, College of Life Sciences & Bio-Engineering, Beijing University of Technology, Beijing 100124, China; Institute of Radiation Medicine, Beijing 100850, China.

Abstract
Carbapenem-reistant enterobacteriaceae (CRE) have been significant increasing recently and are highly endemic in China. Several studies demonstrated the prevalence of antibiotic resistance determinants (ARD) in CRE clinical isolates, but there was no comprehensive overview based on ARDs among CRE clinical isolates in Mainland, China. The objectives of this study was assess the prevalence and distribution pattern of carbapenemase genes, ESBL genes, AmpC-encoding genes, aminoglycoside resistant genes and PMQR among CRE clinical isolates in Mainland, China. A systematic literature review was performed by searching different electronic databases including: Pubmed, Embase, CNKI, Wanfang and CQVIP. A random effect model was used to perform the meta-analysis based on comprehensive meta-analysis software.43 studies were included in this meta-analysis. The pooled prevalence of Carbapenemase genes, ESBL genes, AmpC-encoding genes, aminoglycoside resistance genes and PMQR genes in CRE clinical isolates of Mainland, China were 73.3% (95% CI=63.4-81.3), 81.8% (95%CI =74.3-87.4), 32.7% (95% CI=18.6-50.9), 60.6% (95% CI=47.4-72.4) and 70.8% (95%CI= 60.9-79), respectively. KPC (26.1%, 95%CI=18.1-36.1) was the most common type in Carbapenemase genes, followed by NDM (18.4%, 95% CI=12.2-26.7). KPC-2 (26.6%, 95% CI=18.3-36.9), NDM-1 (14%, 95% CI=9.4-20.1), IMP-4 (10.6%, 95% CI=6.6-16.6), VIM-1 (6.1%, 95% CI=3.3-11.3) and OXA-1 (9.8%, 95%CI=3.1-27.3) were the predominant type of a wide range of KPC, NDM, IMP, VIM and OXA variant genes. CTX-M-15 (32.2%, 95%CI= 20.1-47.1), SHV-12 (23.2%, 95% CI=16.5-31.5) and TEM-1 (54.5%, 95%CI=40-68.2) were the main type of CTX-M, SHV and TEM-1 variant genes. CMY-42 (17.1%, 95% CI=5.0-44.7), aac(6’)-Ib (49.0%, 95% CI=36.4-61.6) and aac(6’)-Ib-cr (37.5%, 95% CI=25.5-51.4) was the most frequently type of AmpC-encoding, aminoglycoside resistance and PMQR genes, respectively. KPC-2, TEM-1, CMY-42, aac(6’)-Ib and aac(6’)-Ib-cr were the most common type of Carbapenemase genes, ESBL genes, AmpC-encoding genes, aminoglycoside resistance genes and PMQR genes.

Keywords
Carbapenemases, ESBL, AmpC, Aminoglycosides, Fluoroquinolones, Carbapenem-resistant enterobacteriaceae

Cite this paper
Huijuan Chen, Qiqi Liu, Gang Wu, Shengqi Wang, Characterization of Carbapenemases, Extended spectrum beta-lactamases, AmpC, Quinolone resistance and Aminoglycoside resistance determinants in Carbapenem -resistant Enterobacteriaceae clinical isolates in Mainland, China, SCIREA Journal of Clinical Medicine. Vol. 6 , No. 3 , 2021 , pp. 213 - 241 .

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