Comparison of thalidomide versus apatinib for prevention of camrelizumab-induced reactive cutaneous capillary endothelial proliferation: a retrospective study

Volume 9, Issue 1, February 2024     |     PP. 141-152      |     PDF (190 K)    |     Pub. Date: April 9, 2023
DOI: 10.54647/cm321042    76 Downloads     651 Views  

Author(s)

Geng Song, Department of oncology, The second affiliated hospital of Anhui Medical University, Hefei 230601, China
Fei-Fei Zhang, Department of oncology, The second affiliated hospital of Anhui Medical University, Hefei 230601, China
Huai-Dong Cheng, Department of oncology, The second affiliated hospital of Anhui Medical University, Hefei 230601, China

Abstract
Objectives: We retrospectively evaluated the effect of thalidomide and apatinib in prevention of camrelizumab-induced reactive cutaneous capillary endothelial proliferation (RCCEP).
Methods: In this study, the clinical data of enrolled patients who received either camrelizumab plus thalidomide therapy (thalidomide group) or camrelizumab plus apatinib therapy (apatinib group) were retrospectively analyzed. The incidences of RCCEP and the adverse events of thalidomide and apatinib were analyzed.
Results: Between June 2017 and October 2022, 30 patients were enrolled. Although the incidence of RCCEP in thalidomide group (4/15, 26.7%) was lower than that in apatinib group (6/15, 40%), the significance threshold was not met (p=0.45). The adverse events of thalidomide included fatigue, constipation, oedema and rash which were mild in severity and manageable, and no treatment-associated interruptions were observed.
Conclusions: Compared with apatinib, thalidomide exhibits a trend towards better prevention of RCCEP with an acceptable tolerance in patients receiving camrelizumab treatment.

Keywords
thalidomide, apatinib, camrelizumab, reactive cutaneous capillary endothelial proliferation

Cite this paper
Geng Song, Fei-Fei Zhang, Huai-Dong Cheng, Comparison of thalidomide versus apatinib for prevention of camrelizumab-induced reactive cutaneous capillary endothelial proliferation: a retrospective study , SCIREA Journal of Clinical Medicine. Volume 9, Issue 1, February 2024 | PP. 141-152. 10.54647/cm321042

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