Correlation between virological indexes and immune inflammation-related factor levels in acute HIV-1-infected patients

Volume 8, Issue 1, February 2023     |     PP. 37-51      |     PDF (1449 K)    |     Pub. Date: January 1, 2023
DOI: 10.54647/cm320980    104 Downloads     2316 Views  

Author(s)

Mingyuan Bi, Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi’an, China
Wen Kang, Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi’an, China
Yongtao Sun, Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi’an, China

Abstract
Purpose: This study aimed to compare the different expression levels of 12 immune inflammation-related factor in plasma of untreated acute HIV-1-infected patients with different HIV-1 RNA or HIV-1 DNA levels.
Methods: 70 acute HIV-1-infected patients without any anti-retrovirus therapy (ART) were selected. The levels of patients’ HIV-1 RNA, HIV-1 DNA and 12 different immune inflammation-related factors in plasma were detected and compared.
Results: The expression levels of CXCL10, CXCL11, CXCL13, IL-6, IL-16 and IL-18 were different between the different HIV-1 RNA level groups and the different HIV-1 DNA level groups. There was no significant difference in the expression levels of the chemokines IL-8, CCL2, CCL20 and CCL22 between the groups. The stratified analysis using 200 cells/μL as the CD4+ T cell count cut-off value showed similar intergroup differences.
Conclusion: CXCL10, CXCL11, CXCL13, IL-6, IL-16 and IL-18 may be involved in the regulation of viral replication or viral reservoirs, and may also be used as important indicators for the evaluation of HIV-1 replication.

Keywords
HIV-1; chemokines; interleukins; HIV-1 RNA; HIV-1 DNA

Cite this paper
Mingyuan Bi, Wen Kang, Yongtao Sun, Correlation between virological indexes and immune inflammation-related factor levels in acute HIV-1-infected patients , SCIREA Journal of Clinical Medicine. Volume 8, Issue 1, February 2023 | PP. 37-51. 10.54647/cm320980

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