CORRELATION BETWEEN GLOMERULAR FILTRATION RATE WITH CALCIUM-PHOSPHATE PRODUCT LEVELS IN CHRONIC KIDNEY DISEASE

Volume 9, Issue 1, February 2024     |     PP. 224-231      |     PDF (176 K)    |     Pub. Date: June 24, 2022
DOI: 10.54647/cm32848    74 Downloads     934 Views  

Author(s)

Rizki Primasari, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia
Hasyim Kasim, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia
Arifin Seweng, Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar 90245, Indonesia
Andi Muhammad Luthfi Parewangi, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia
Endy Adnan, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia
Syakib Bakri, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia
Haerani Rasyid, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia

Abstract
Background: In chronic kidney disease (CKD) patients, calcium and phosphate homeostasis disorders occur. Decreased renal function will result in a decrease in phosphate excretion. In stage 3b CKD, the kidney is no longer able to compensate for phosphate burden adequately, and as a result hyperphosphatemia arises. The decline in renal function also causes calcitriol level to decline, which will be followed by undermined calcium absorption in the intestine. The application of calcium-phosphate binders and calcitrion in CKD will normalize phosphate and calcium levels in the blood. However, it can bring about hypercalcemia episodes. This research attempted to figure out the relationship between glomerular filtration rate (GFR) and calcium-phosphate (CaxP) product in CKD.
Methods: This is an observational study with a cross-sectional approach that involved 80 CKD subjects, distributed into stage 3 (n = 20), stage 4 (n = 20), non-dialysis stage 5 (n = 20), and dialysis stage 5 (n = 20) CKD patients at Wahidin Sudirohusodo Hospital and Unhas Hospital of Makassar from April to August of 2021. Phosphate levels were measured using ELISA kit (Immutopics). The results of the statistical tests conducted would be considered significant if p < 0.05.
Results: The CaxP product averages across stages were as follows: stage 3: 32.82 ± 10.77 mg2/dL2; stage 4: 32.95 ± 8.11 mg2/dL2; non-dialysis stage 5: 47.93 ± 21.28 mg2/dL2; and dialysis stage 5: 45.58 ± 24.74 mg2/dL2. The figures above showed that stage 3 was not significantly different from stage 4 (p = 0.986), but it was significantly different from non-dialysis stage 5 (p = 0.009). A significant difference was also found between stage 4 and non-dialysis stage 5 (p = 0.009). The proportion of subjects with high CaxP product (CaxP > 55 mg2/dL2) in CKD stage 3 was 5% (n = 1), in CKD stage 4 5% (n = 1), in non-dialysis stage 5 25% (n = 5), and in dialysis stage 5 35% (n = 7).
Conclusion: The lower the GFR the greater the CaxP product. The proportion of subjects with high CaxP product increased with the decrease in GFR.

Keywords
Phosphate; Calcium-Phosphate Product; Glomerular Filtration Rate; Chronic Kidney Disease

Cite this paper
Rizki Primasari, Hasyim Kasim, Arifin Seweng, Andi Muhammad Luthfi Parewangi, Endy Adnan, Syakib Bakri, Haerani Rasyid, CORRELATION BETWEEN GLOMERULAR FILTRATION RATE WITH CALCIUM-PHOSPHATE PRODUCT LEVELS IN CHRONIC KIDNEY DISEASE , SCIREA Journal of Clinical Medicine. Volume 9, Issue 1, February 2024 | PP. 224-231. 10.54647/cm32848

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