Relationship Between Coronavirus Disease 2019 and Alzheimer’s Disease

Volume 6, Issue 5, October 2021     |     PP. 309-328      |     PDF (219 K)    |     Pub. Date: August 29, 2021
DOI: 10.54647/cm32594    84 Downloads     3412 Views  


Farage Ftiha, BS, Medical Student at New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA
Yakubmiyer Musheyev, BS, Medical Student at New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA
Henry Jradeh, Undergraduate student at City University of New York-Brooklyn College, Brooklyn, NY, USA

The Covid 19 pandemic is causing global morbidity and mortality, straining health care systems, and disrupting society, putting individuals with Alzheimer's disease and related dementias (ADRD) at risk of significant harm. In this review paper, we examine the current and expected impact of the pandemic on individuals with ADRD. Recent case studies show that Covid 19 can have a negative effect on patients with neurological disorders such as Alzheimer's Disease (AD). Our team has analyzed the extensive amount of papers that explore this connection and have summarized the ones most relevant. COVID 19 is known to produce neurological manifestations and is able to infect the Central Nervous System, potentially via the olfactory bulb. Patients with Alzheimer's often have accompanying complications that make them particularly vulnerable. It is important to also look at the indirect social effects of the pandemic, such as limited social interaction and an increase in anxiety.

Covid 19, Neurology, Alzheimer’s Disease, Related Dementia, SARS CoV 2, ACE 2, Olfactory Bulb, Accelerated Onset

Cite this paper
Farage Ftiha, BS, Yakubmiyer Musheyev, BS, Henry Jradeh, Relationship Between Coronavirus Disease 2019 and Alzheimer’s Disease , SCIREA Journal of Clinical Medicine. Volume 6, Issue 5, October 2021 | PP. 309-328. 10.54647/cm32594


[ 1 ] Breijyeh, Z., & Karaman, R. (2020). Comprehensive Review on Alzheimer's Disease: Causes and Treatment. Molecules (Basel, Switzerland), 25(24), 5789.
[ 2 ] Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., & Jones, E. (2011). Alzheimer's disease. Lancet (London, England), 377(9770), 1019–1031.
[ 3 ] Høgh P. (2017). Ugeskrift for laeger, 179(12), V09160686.
[ 4 ] Atri A. (2019). The Alzheimer's Disease Clinical Spectrum: Diagnosis and Management. The Medical clinics of North America, 103(2), 263–293.
[ 5 ] Weller, J., & Budson, A. (2018). Current understanding of Alzheimer's disease diagnosis and treatment. F1000Research, 7, F1000 Faculty Rev-1161.
[ 6 ] A Armstrong R. (2019). Risk factors for Alzheimer's disease. Folia neuropathologica, 57(2), 87–105.
[ 7 ] Reitz C. (2015). Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities. Expert review of molecular diagnostics, 15(3), 339–348.
[ 8 ] Crous-Bou, M., Minguillón, C., Gramunt, N., & Molinuevo, J. L. (2017). Alzheimer's disease prevention: from risk factors to early intervention. Alzheimer's research & therapy, 9(1), 71.
[ 9 ] Tiwari, S., Atluri, V., Kaushik, A., Yndart, A., & Nair, M. (2019). Alzheimer's disease: pathogenesis, diagnostics, and therapeutics. International journal of nanomedicine, 14, 5541–5554.
[ 10 ] Sochocka, M., Zwolińska, K., & Leszek, J. (2017). The Infectious Etiology of Alzheimer's Disease. Current neuropharmacology, 15(7), 996–1009.
[ 11 ] Rahman, M. A., Islam, K., Rahman, S., & Alamin, M. (2021). Neurobiochemical Cross-talk Between Covid 19 and Alzheimer's Disease. Molecular neurobiology, 58(3), 1017–1023.
[ 12 ] Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for Covid 19. Int Forum Allergy Rhinol. 2020;10(8):944–950. doi: 10.1002/alr.22587. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
[ 13 ] Burns A. Might olfactory dysfunction be a marker of early Alzheimer’s disease? Lancet. 2000;355:84–85. doi: 10.1016/S0140-6736(99)90402-6. [PubMed] [CrossRef] [Google Scholar]
[ 14 ] Li J, Long X, Huang H, Tang J, Zhu C, Hu S, Wu J, Li J, Lin Z, Xiong N. Resilience of Alzheimer's Disease to Covid 19. J Alzheimers Dis. 2020;77(1):67-73. doi: 10.3233/JAD-200649. PMID: 32804094; PMCID: PMC7592684.
[ 15 ] Lechien, J. R., Chiesa-Estomba, C. M., De Siati, D. R., Horoi, M., Le Bon, S. D., Rodriguez, A., Dequanter, D., Blecic, S., El Afia, F., Distinguin, L., Chekkoury-Idrissi, Y., Hans, S., Delgado, I. L., Calvo-Henriquez, C., Lavigne, P., Falanga, C., Barillari, M. R., Cammaroto, G., Khalife, M., Leich, P., … Saussez, S. (2020). Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (Covid 19): a multicenter European study. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 277(8), 2251–2261.
[ 16 ] Meng, X., Deng, Y., Dai, Z., & Meng, Z. (2020). Covid 19 and anosmia: A review based on up-to-date knowledge. American journal of otolaryngology, 41(5), 102581.
[ 17 ] Mok, V., Pendlebury, S., Wong, A., Alladi, S., Au, L., Bath, P. M., Biessels, G. J., Chen, C., Cordonnier, C., Dichgans, M., Dominguez, J., Gorelick, P. B., Kim, S., Kwok, T., Greenberg, S. M., Jia, J., Kalaria, R., Kivipelto, M., Naegandran, K., Lam, L., … Scheltens, P. (2020). Tackling challenges in care of Alzheimer's disease and other dementias amid the Covid 19 pandemic, now and in the future. Alzheimer's & dementia : the journal of the Alzheimer's Association, 16(11), 1571–1581.
[ 18 ] El Haj, M., Altintas, E., Chapelet, G., Kapogiannis, D., & Gallouj, K. (2020). High depression and anxiety in people with Alzheimer's disease living in retirement homes during the Covid 19 crisis. Psychiatry research, 291, 113294.
[ 19 ] Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., Miao, X., Li, Y., & Hu, B. (2020). Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA neurology, 77(6), 683–690.
[ 20 ] Abboud, H., Abboud, F. Z., Kharbouch, H., Arkha, Y., El Abbadi, N., & El Ouahabi, A. (2020). Covid 19 and SARS-Cov-2 Infection: Pathophysiology and Clinical Effects on the Nervous System. World neurosurgery, 140, 49–53.
[ 21 ] Moriguchi, T., Harii, N., Goto, J., Harada, D., Sugawara, H., Takamino, J., Ueno, M., Sakata, H., Kondo, K., Myose, N., Nakao, A., Takeda, M., Haro, H., Inoue, O., Suzuki-Inoue, K., Kubokawa, K., Ogihara, S., Sasaki, T., Kinouchi, H., Kojin, H., … Shimada, S. (2020). A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 94, 55–58.
[ 22 ] Yan, R., Zhang, Y., Li, Y., Xia, L., Guo, Y., & Zhou, Q. (2020). Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science (New York, N.Y.), 367(6485), 1444–1448.
[ 23 ] Baig, A. M., Khaleeq, A., Ali, U., & Syeda, H. (2020). Evidence of the Covid 19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS chemical neuroscience, 11(7), 995–998.
[ 24 ] Gheblawi, M., Wang, K., Viveiros, A., Nguyen, Q., Zhong, J. C., Turner, A. J., Raizada, M. K., Grant, M. B., & Oudit, G. Y. (2020). Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2. Circulation research, 126(10), 1456–1474.
[ 25 ] Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., Manson, J. J., & HLH Across Speciality Collaboration, UK (2020). Covid 19: consider cytokine storm syndromes and immunosuppression. Lancet (London, England), 395(10229), 1033–1034.
[ 26 ] Bohmwald, K., Gálvez, N., Ríos, M., & Kalergis, A. M. (2018). Neurologic Alterations Due to Respiratory Virus Infections. Frontiers in cellular neuroscience, 12, 386.
[ 27 ] Zhou, Y., Xu, J., Hou, Y., Leverenz, J. B., Kallianpur, A., Mehra, R., Liu, Y., Yu, H., Pieper, A. A., Jehi, L., & Cheng, F. (2021). Network medicine links SARS-CoV-2/Covid 19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment. Alzheimer's research & therapy, 13(1), 110.
[ 28 ] Toniolo, S., Scarioni, M., Di Lorenzo, F., Hort, J., Georges, J., Tomic, S., Nobili, F., Frederiksen, K. S., & Management Group of the EAN Dementia and Cognitive Disorders Scientific Panel (2021). Dementia and Covid 19, a Bidirectional Liaison: Risk Factors, Biomarkers, and Optimal Health Care. Journal of Alzheimer's disease : JAD, 10.3233/JAD-210335. Advance online publication.
[ 29 ] Zubair, A. S., McAlpine, L. S., Gardin, T., Farhadian, S., Kuruvilla, D. E., & Spudich, S. (2020). Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review. JAMA neurology, 77(8), 1018–1027.
[ 30 ] Naughton, S. X., Raval, U., & Pasinetti, G. M. (2020). Potential Novel Role of Covid 19 in Alzheimer's Disease and Preventative Mitigation Strategies. Journal of Alzheimer's disease : JAD, 76(1), 21–25.
[ 31 ] Calderón-Garcidueñas, L., Torres-Jardón, R., Franco-Lira, M., Kulesza, R., González-Maciel, A., Reynoso-Robles, R., Brito-Aguilar, R., García-Arreola, B., Revueltas-Ficachi, P., Barrera-Velázquez, J. A., García-Alonso, G., García-Rojas, E., Mukherjee, P. S., & Delgado-Chávez, R. (2020). Environmental Nanoparticles, SARS-CoV-2 Brain Involvement, and Potential Acceleration of Alzheimer's and Parkinson's Diseases in Young Urbanites Exposed to Air Pollution. Journal of Alzheimer's disease : JAD, 78(2), 479–503.
[ 32 ] Brown, E. E., Kumar, S., Rajji, T. K., Pollock, B. G., & Mulsant, B. H. (2020). Anticipating and Mitigating the Impact of the Covid 19 Pandemic on Alzheimer's Disease and Related Dementias. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 28(7), 712–721.
[ 33 ] Foley NC, Affoo RH, Martin RE. A systematic review and meta-analysis examining pneumonia-associated mortality in dementia. Dement Geriatr Cogn Disord. 2015;39(1-2):52-67. doi: 10.1159/000367783. Epub 2014 Oct 22. PMID: 25342272.
[ 34 ] Wu JT, Leung K, Bushman M. Estimating clinical severity of Covid 19 from the transmission dynamics in Wuhan. China Nat Med. 2020;26:506–510.
[ 35 ] Bauer K, Schwarzkopf L, Graessel E. A claims data-based comparison of comorbidity in individuals with and without dementia. BMC Geriatr. 2014;14:1–13
[ 36 ] Zhou F, Yu T, Du R. Clinical course and risk factors for mortality of adult inpatients with Covid 19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062.
[ 37 ] Ciaccio, M., Lo Sasso, B., Scazzone, C., Gambino, C. M., Ciaccio, A. M., Bivona, G., Piccoli, T., et al. (2021). Covid 19 and Alzheimer’s Disease. Brain Sciences, 11(3), 305. MDPI AG. Retrieved from
[ 38 ] Jiménez-Ruiz, A.; García-Grimshaw, M.; Ruiz-Sandoval, J.L. Neurological manifestations of Covid 19. Gac. Med. Mex. 2020, 156, 4
[ 39 ] Condie L. O. (2020). Neurotropic mechanisms in Covid 19 and their potential influence on neuropsychological outcomes in children. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 26(5), 577–596.
[ 40 ] Patsali, M. E., Mousa, D. V., Papadopoulou, E., Papadopoulou, K., Kaparounaki, C. K., Diakogiannis, I., & Fountoulakis, K. N. (2020). University students' changes in mental health status and determinants of behavior during the Covid 19 lockdown in Greece. Psychiatry research, 292, 113298.
[ 41 ] Palmer, K., Monaco, A., Kivipelto, M., Onder, G., Maggi, S., Michel, J. P., Prieto, R., Sykara, G., & Donde, S. (2020). The potential long-term impact of the Covid 19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing. Aging clinical and experimental research, 32(7), 1189–1194.
[ 42 ] Mohammadi, S.; Moosaie, F.; Aarabi, M.H. Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms. Mol. Neurobiol. 2020, 57, 5263–5275