EVALUATION OF NEURO-COGNITIVE FUNCTIONS IN PATIENT WITH OBSTRUCTIVE SLEEP APNEA SYNDROME

Volume 9, Issue 1, February 2024     |     PP. 76-85      |     PDF (138 K)    |     Pub. Date: March 1, 2021
DOI: 10.54647/cm32442    152 Downloads     1394 Views  

Author(s)

Aydın Kant, Department of Chest Diseases, Trabzon Vakfıkebir State Hospital, Trabzon, Turkey
Hacer Kuzu Okur, Acibadem Altunizade Hospital, Chest Disease Unit, Istanbul, Turkey
Zerrin Pelin, Department of Health Sciences, Hasan Kalyoncu University, Gaziantep, Turkey
Hatice Türker, Süreyyapaşa Chest Diseases and Chest Surgery Training and Research Hospital.

Abstract
Objective: Obstructive sleep apnea syndrome (OSAS) is a disease that causes recurrent episodes of apnea, disrupting sleep integrity, significantly impairing functionality and causing neuropsychiatric disorders. In our study, it was aimed to determine whether there is a relationship between theseverity of OSAS and anxiety and depression and the cognitive dysfunction that may occur due to OSAS and the neuropsychiatric exposure levels of the patients.
Methods: The study was performed prospectively. Apnea hypopnea index (AHI) results were determined by polysomnography (PSG). Hospital Anxiety and Depression Scale (HAD) and Trail Making Test were applied to patients with OSAS to determine the ir neuropsychiatric conditions. Findings were evaluated using descriptive statistical methods.
Results: 45 patients were included in the study. There was no statistically significant relationship between AHI score and anxiety and depression in the patients included in thestudy (p> 0.05). There was no statistically significant difference between AHI scores and Trace A and Trace B durations, Trace A andTrace B errorrates (p> 0.05). While there was no statistically significant difference between the presence of anxiety and the durations of Trace A and Trace B and the rates of Trace A error (p> 0.05), the rates of Trace B error were statistically significantly different (p = 0.035). There was no statistically significant difference between the presence of depression and the duration of Trace A and B, and the rates of Trace A and B error (p> 0.05).
Conclusions: The rates of making trace B errors in anxiety cases are higher in patients with OSAS compared to cases without anxiety. However, with the present findings, more studies are needed to determine whether cognitive dysfunction in patients with OSAS causes a change in the perception of anxiety and depression symptoms in this patient population.

Keywords
OSAS, Neuropsychiatric disorders, Anxiety, Depression

Cite this paper
Aydın Kant, Hacer Kuzu Okur, Zerrin Pelin, Hatice Türker, EVALUATION OF NEURO-COGNITIVE FUNCTIONS IN PATIENT WITH OBSTRUCTIVE SLEEP APNEA SYNDROME , SCIREA Journal of Clinical Medicine. Volume 9, Issue 1, February 2024 | PP. 76-85. 10.54647/cm32442

References

[ 1 ] Guilleminault C, Stoohs R, Clerk A, et al. From obstructive sleep apnea syndrome to upper airway resistance syndrome, consistency of day time sleepiness. Sleep, 1992; 15: 13-16.
[ 2 ] El-AdB, LavieP. Effect of sleepapnea on cognitionandmood. International Review of Psychiatry, 2005; 17(4): 277-282.
[ 3 ] Sertöz ÖÖ, Mete HE. Bedensel hastalıklarda depresyon. Klinik Psikiyatri, 2004; Ek 2: 63-69.
[ 4 ] Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand, 1983; 67(6):361-370.
[ 5 ] Marsel Mesulam. Davranışsal ve Kognitif Nörolojinin İlkeleri. İkinci baskı. Çeviri Editörü: İ. Hakan Gürvit. Yelkovan yayıncılık. 2004.
[ 6 ] Kayalı M. Uyku Bozuklukları. In: Yüksel N (ed). Ruhsal Hastalıklar. Ankara: Çizgi Tıp Yayınevi, 361-86. 2001.
[ 7 ] Pillar G, Lavie P. Psychiatric symptoms in sleep apnea syndrome: effects of gender and respiratory disturbance index. Chest, 1998; 114: 697-703.
[ 8 ] Andrews JG, Oei TP. The roles of depression and anxiety in the understanding and treatment of obstructive sleep apnea syndrome. Clin Psychol Rev, 2004; 24: 1031-1049.
[ 9 ] Reynolds CF, Kupfer DJ, McEachran AB, et al. Depressive psychpathology in male sleep apneics. J Clin Psychiatry, 1989; 45:287-290.
[ 10 ] Kales A, Cadwell AB, Cadieux RJ, et al. Severe obstructive sleep apnea-II: associated psychopathology and psychosocial consequences. J Chron Dis, 1985; 38:427-434.
[ 11 ] Sforza E, De Saint Hilaire Z, Pelissolo A, et al. Personality, anxiety and mood traits in patients with sleep-related breathing disorders: effect of reduced day time alertness. Sleep Med, 2002; 3:139-145.
[ 12 ] Aloia MS, Arnedt JT, Smith L, et al. Examining the construct of depression in obstructive sleep apnea syndrome. Sleep Med, 2005; 6 (2):115-121.
[ 13 ] Doherty LS, Kiely JL, Lawless G, et al. Impact of nasal continuous positive airway pressure therapy on the quality of life of bedpartners of patients with obstructive sleep apnea syndrome. Chest, 2003; 124:2209-2214.
[ 14 ] Kjelsberg FN, Ruud EA, Stavem K. Predictors of Symptoms of Anxiety and Depression in obstructive sleep apnea. Sleep Medicine, 2005; 6:341-346.
[ 15 ] Yue W, Hao W, Liu P, et al. A case-control study on psycological symptoms in sleep apnea-hypopnea syndrome. Can J Psychiatry, 2003; 48:318-323.
[ 16 ] Aloia MS, Arnedt JT, Davis JD, et al. Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review. J Int Neuropsychol Soc. 2004;10(5):772-785.
[ 17 ] Verstraeten E, Cluydts R, Pevernagie D, et al. Executive function in sleep apnea: controlling for attentional capacity in assessing executive attention. Sleep, 2004; 27:685-693.
[ 18 ] Saunamaki T, Jehkonen M. A review of executive functions in obstructive sleep apnea syndrome. Acta Neurol Scand, 2007; 115: 1–11.
[ 19 ] Cohen-Zion M, Stepnowsky C, Marler, et al. Changes in cognitive function associated with sleep disordered breathing in older people. J Am Geriatr Soc, 2001; 49(12):1622-1627.
[ 20 ] Bedard MA, Montplaisir J, Malo J, et al. Persistent neuropsychological deficits and vigilance impairment in sleep apnea syndrome after treatment with continuous positive airway pressure (CPAP). J Clin Exp Neuropsychol, 1993;15:330-341.
[ 21 ] Knight H, Millman RP, Gur RC, et al. Clinical significance of sleep apnea in the elderly. Am Rev Respir Dis, 1987; 136:845-850.