Volume 5, Number 3 (2020)
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Home > Journals > SCIREA Journal of Chemistry > Archive > Paper Information

Evaluation of antitumour potency of Sonchus oleraceus L. peptides on human gastric cancers In vitro and In vivo

Volume 5, Issue 3, June 2020    |    PP. 47-70    |PDF (1469 K)|    Pub. Date: June 19, 2020
16 Downloads     233 Views  

Author(s)
Jie Liu, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518020, China;School of Medicine, Shenzhen University, Shenzhen 518060, China.
Huailing Wang, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518020, China; College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Xiaowei Zeng, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.
Xizhuo Sun, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518020, China.
Zhendan He, College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Liteng Yang, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518020, China.
Shuqi Qiu, Longgang ENT Hospital & Shenzhen ENT Institute, Shenzhen, 518060, China.
Lin Mei, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.

Abstract
The Sonchus oleraceus L. is widely consumed as vegetables, tea drink and traditional medicine. However, the anti-tumor property of Sonchus oleraceus L peptides (SOPs) was rarely explored. The present study evaluated the anti-gastric cancer potency of SOPs in vivo. We found that SOP-1 (FKEHGY) significantly inhibited the proliferation of the SGC-7901 cells with an IC50 of 0.10 ± 0.01 mM (24 h), and inhibited the growth of the gastric tumor in the experimental mice. Further study revealed that SOP-1 blocked the cell cycle in G0/G1 phase, and accompanied with inhibiting the cyclins expression of the gastric cancer cells collected from the tumor tissue of the SOP-1 treated mice. In addition, SOP-1 significantly increased the Bax/Bcl-2 ratio and induced the mitochondrial membrane potential collapse, and activated Caspases, thereby inducing the gastric cancer cells apoptosis. The current findings reveal that SOP-1 is a potent cytotoxic agent against gastric cancer cells in vivo and its cytotoxicity is mediated through induction of apoptosis and cell cycle arrest.

Keywords
Sonchus oleraceus L.; Gastric cancer; Cell cycle arrest, Apoptosis

Cite this paper
Jie Liu, Huailing Wang, Xiaowei Zeng, Xizhuo Sun, Zhendan He, Liteng Yang, Shuqi Qiu, Lin Mei, Evaluation of antitumour potency of Sonchus oleraceus L. peptides on human gastric cancers In vitro and In vivo, SCIREA Journal of Chemistry. Vol. 5 , No. 3 , 2020 , pp. 47 - 70 .

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