Volume 4, Number 1 (2020)
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Home > Journals > SCIREA Journal of Medicine > Archive > Paper Information

Hypercalcemia presenting as the initial manifestation of Lymphoma

Volume 4, Issue 1, February 2020    |    PP. 1-9    |PDF (186 K)|    Pub. Date: May 10, 2020
15 Downloads     315 Views  

Venu Madhav Konala, Internist and Medical Oncologist, Ashland Bellefonte Cancer Center, Ashland, KY, USA
Sara Ashraf, Fellow in hematology and oncology, Marshall University, Joan C Edwards School of Medicine, Huntington, WV, USA
Sreedhar Adapa, Attending Nephrologist, The Nephrology group, Fresno, CA, USA
Srikanth Naramala, Attending Rheumatologist, Department of Rheumatology, Adventist Medical Center, Hanford, CA, USA
Subhasish Bose, Lynchburg Nephrology Physicians, Lynchburg, VA, USA
Sasmit Roy, Lynchburg Nephrology Physicians, Lynchburg, VA, USA
Chetan Brahma Kammari, Hospitalist, Internal Medicine, Cape Fear Valley Hosital, Fayetteville, NC, USA
Bhaskar Reddy Madhira, Fellow in Hematology and Oncology, Sunny Upstate Medical University, Syracuse, NY, USA

Non-Hodgkin’s lymphoma, hypercalcemia, malignancy, B-cell lymphoma, T-cell lymphoma

Hypercalcemia as an initial presentation of malignant lymphoma is uncommon as many patients with lymphoma develop hypercalcemia late in the course of disease with extensive bone involvement. Also, among subgroups of lymphomas, hypercalcemia is more common in adult T cell lymphomas rather than B-cell lymphomas. We present a case of mature B cell lymphoma presenting as hypercalcemia in the absence of bone lesions. The case report discusses the pathogenesis, symptoms, and treatment of hypercalcemia.

Cite this paper
Venu Madhav Konala, Sara Ashraf, Sreedhar Adapa, Srikanth Naramala, Subhasish Bose, Sasmit Roy, Chetan Brahma Kammari, Bhaskar Reddy Madhira, Hypercalcemia presenting as the initial manifestation of Lymphoma, SCIREA Journal of Medicine. Vol. 4 , No. 1 , 2020 , pp. 1 - 9 .


[ 1 ] Shuso Suemaru, Jingo Kageyama, Zenske Ota, Taisuke Ohnoshi, Kenji Sakamoto and Junta Kaura, A Case of Non Hodgkins Lymphoma associated with Hypercalcemia. Acta Med Okayama 1991 45:1 55-59.
[ 2 ] Malcolm Cox, Lymphoma, Hypercalcemia and the Sunshine Vitamin Annals of Internal Medicine 1994, 21:9 709-712
[ 3 ] Andrew F Stewart, Hypercalcemia associated with cancer. NEJM2005 352:4 373-379
[ 4 ] Hirotaka Takasaki, Heiwa Kanamori, Maki Takabayashi, Satoshi Yamaji, Hideyuki Koharazawa, Jun Taguchi, Katsumichi Fujimaki, and Yoshiaki Ishigatsubo Non Hodgkins Lymphoma Presenting as multiple bone lesions and Hypercalcemia. American Journal of Hematology 2006. 81: 439-442
[ 5 ] Franco Lumachi, Antonella Brunello, Anna Roma, Umberto Basso, Cancer Induced Hypercalcemia. Anticancer Research 2009. 29: 1551-1556
[ 6 ] Martin Hewison, Vitaly Kantorovich, Harley B Liker, Andre J Van Herle, Pejman Cohan, Daniel Zehnder and John S Adaams Vitamin D Mediated Hypercalcemia in Lymphoma: Evidence of Hormone Production by Tumour Adjacent Macrophages. Journal of Bone and Mineral Research 2003, 18:3 579-582
[ 7 ] John F Seymour,MBBS; Robert F Gagel MD; Frederich B Hagemeister, MD;, Meletios A Dimopoulos,MD; and Fernando Cabanillas, MD Calcitriol Production in Hypercalcemic and Normocalcemic patients with Non Hodgkins Lymphoma Annals of Internal Medicine 1994; 121:633-640
[ 8 ] Pelosof LC, Gerber DE. Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clin Proc 2010; 85: 838-854 [PMID: 20810794 DOI: 10.4065/mcp.2010.0099]
[ 9 ] Mazzone PJ, Arroliga AC. Endocrine paraneoplastic syndromes in lung cancer. Curr Opin Pulm Med 2003; 9: 313-320 [PMID: 12806246 DOI: 10.1097/00063198-200307000-00012]
[ 10 ] Clines GA. Mechanisms and treatment of hypercalcemia of malignancy. Curr Opin Endocrinol Diabetes Obes 2011; 18: 339-346 [PMID: 21897221 DOI: 10.1097/MED.0b013e32834b4401]
[ 11 ] D A Hanley, J D Adachi, A Bell et al. Denosumab: mechanism of action and clinical outcomes. Int J Clin Pract. 2012 Dec; 66(12): 1139–1146. [PMID: 22967310]
[ 12 ] Stopeck AT, Lipton A, Body JJ, et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol 2010; 28: 5132-5139 [PMID: 21060033 DOI: 10.1200/JCO.2010.29.7101]

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