Volume 2, Number 1 (2017)
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Home > Journals > SCIREA Journal of Pharmacy > Archive > Paper Information

Transformation of a Nomogram for Drug-induced QT-Prolongation to a Computerized Neural Network

Volume 2, Issue 1, February 2017    |    PP. 1-6    |PDF (333 K)|    Pub. Date: February 28, 2017
86 Downloads     1308 Views  

Author(s)
Timothy J Smith, RPh, PhD, Department of Physiology and Pharmacology Thomas J Long School of Pharmacy and Health Sciences University of the Pacific Stockton, California 95211 USA

Abstract
Drug-induced prolongation of the QT interval of the electrocardiogram is well recognized as a risk for increased mortality. A nomogram relating QT-interval to heart rate has been previously developed to assess this risk. Since other risk factors may be operative, a computerized neural network was derived from the nomogram. The value of such a neural network includes the subsequent identification of factors that may modify the risk associated with cardiotoxic drug therapy, providing an additional predictive tool that may be used to reduce this risk.

Keywords
: Neural Networks, Nomogram, QT-Prolongation

Cite this paper
Timothy J Smith, RPh, PhD, Transformation of a Nomogram for Drug-induced QT-Prolongation to a Computerized Neural Network, SCIREA Journal of Pharmacy. Vol. 2 , No. 1 , 2017 , pp. 1 - 6 .

References

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[ 2 ] Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100:609–615.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703227/
[ 3 ] QT Interval Nomogram, WikiTox; January 17, 2017, http://curriculum.toxicology.wikispaces.net/file/detail/QT+Nomogram+File_public.xls
[ 4 ] Forsström JJ1, Dalton KJ. Artificial neural networks for decision support in clinical medicine. Ann Med. 1995 Oct;27(5):509-17.https://www.ncbi.nlm.nih.gov/pubmed/8541025
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[ 6 ] Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350:1013–1022. http://www.nejm.org/doi/full/10.1056/NEJMra032426

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