Volume 2, Number 1 (2017)
Year Launched: 2016
Journal Menu
Archive
Previous Issues
Why Us
-  Open Access
-  Peer-reviewed
-  Rapid publication
-  Lifetime hosting
-  Free indexing service
-  Free promotion service
-  More citations
-  Search engine friendly
Contact Us
Email:   service@scirea.org
Home > Journals > SCIREA Journal of Pharmacy > Archive > Paper Information

Transformation of a Nomogram for Drug-induced QT-Prolongation to a Computerized Neural Network

Volume 2, Issue 1, February 2017    |    PP. 1-6    |PDF (333 K)|    Pub. Date: February 28, 2017
   237 Downloads     2748 Views  

Author(s)
Timothy J Smith, RPh, PhD, Department of Physiology and Pharmacology Thomas J Long School of Pharmacy and Health Sciences University of the Pacific Stockton, California 95211 USA

Abstract
Drug-induced prolongation of the QT interval of the electrocardiogram is well recognized as a risk for increased mortality. A nomogram relating QT-interval to heart rate has been previously developed to assess this risk. Since other risk factors may be operative, a computerized neural network was derived from the nomogram. The value of such a neural network includes the subsequent identification of factors that may modify the risk associated with cardiotoxic drug therapy, providing an additional predictive tool that may be used to reduce this risk.

Keywords
: Neural Networks, Nomogram, QT-Prolongation

Cite this paper
Timothy J Smith, RPh, PhD, Transformation of a Nomogram for Drug-induced QT-Prolongation to a Computerized Neural Network, SCIREA Journal of Pharmacy. Vol. 2 , No. 1 , 2017 , pp. 1 - 6 .

References

[ 1 ] Andrew J. Sauer, Christopher Newton-Cheh. Clinical and Genetic Determinants of Torsade de Pointes Risk. Circulation. 2012;125:1684-1694. http://circ.ahajournals.org/content/125/13/1684
[ 2 ] Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100:609–615.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703227/
[ 3 ] QT Interval Nomogram, WikiTox; January 17, 2017, http://curriculum.toxicology.wikispaces.net/file/detail/QT+Nomogram+File_public.xls
[ 4 ] Forsström JJ1, Dalton KJ. Artificial neural networks for decision support in clinical medicine. Ann Med. 1995 Oct;27(5):509-17.https://www.ncbi.nlm.nih.gov/pubmed/8541025
[ 5 ] Padar, S. and Smith, T.J. Transformation of an acetaminophen toxicity nomogram to an artificial neural network. International Journal of Clinical Pharmacology and Therapeutics 37:446-448 (1999).https://www.ncbi.nlm.nih.gov/pubmed/?term=int+J+Clin+Pharmacol+Ther+37%3A446-448+1999
[ 6 ] Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350:1013–1022. http://www.nejm.org/doi/full/10.1056/NEJMra032426

Submit A Manuscript
Review Manuscripts
Join As An Editorial Member
Most Views
Article
by Sergey M. Afonin
3057 Downloads 63184 Views
Article
by Jian-Qiang Wang, Chen-Xi Wang, Jian-Guo Wang, HRSCNP Research Team
15 Downloads 52800 Views
Article
by Syed Adil Hussain, Taha Hasan Associate Professor
2418 Downloads 25464 Views
Article
by Omprakash Sikhwal, Yashwant Vyas
2486 Downloads 21374 Views
Article
by Munmun Nath, Bijan Nath, Santanu Roy
2364 Downloads 20995 Views
Upcoming Conferences