Author(s)
Timothy J Smith, RPh, PhD, Department of Physiology and Pharmacology Thomas J Long School of Pharmacy and Health Sciences University of the Pacific Stockton, California 95211 USA

Abstract
Drug-induced prolongation of the QT interval of the electrocardiogram is well recognized as a risk for increased mortality. A nomogram relating QT-interval to heart rate has been previously developed to assess this risk. Since other risk factors may be operative, a computerized neural network was derived from the nomogram. The value of such a neural network includes the subsequent identification of factors that may modify the risk associated with cardiotoxic drug therapy, providing an additional predictive tool that may be used to reduce this risk.

Keywords
: Neural Networks, Nomogram, QT-Prolongation

Cite this paper
Timothy J Smith, RPh, PhD, Transformation of a Nomogram for Drug-induced QT-Prolongation to a Computerized Neural Network, SCIREA Journal of Pharmacy. Vol. 2 , No. 1 , 2017 , pp. 1 - 6 .

References

[ 1 ]	Andrew J. Sauer, Christopher Newton-Cheh. Clinical and Genetic Determinants of Torsade de Pointes Risk. Circulation. 2012;125:1684-1694. http://circ.ahajournals.org/content/125/13/1684
[ 2 ]	Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100:609–615.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703227/
[ 3 ]	QT Interval Nomogram, WikiTox; January 17, 2017, http://curriculum.toxicology.wikispaces.net/file/detail/QT+Nomogram+File_public.xls
[ 4 ]	Forsström JJ1, Dalton KJ. Artificial neural networks for decision support in clinical medicine. Ann Med. 1995 Oct;27(5):509-17.https://www.ncbi.nlm.nih.gov/pubmed/8541025
[ 5 ]	Padar, S. and Smith, T.J. Transformation of an acetaminophen toxicity nomogram to an artificial neural network. International Journal of Clinical Pharmacology and Therapeutics 37:446-448 (1999).https://www.ncbi.nlm.nih.gov/pubmed/?term=int+J+Clin+Pharmacol+Ther+37%3A446-448+1999
[ 6 ]	Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350:1013–1022. http://www.nejm.org/doi/full/10.1056/NEJMra032426