METABOLIC COMFORT IN ONCOLOGY AND FREE AMINO ACIDS: PERSPECTIVES FOR THE USE OF THEIR REGULATORY ACTIONS IN PHYSIOLOGICAL CONCENTRATIONS
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Author(s)
Abstract
On the basis of experimental data we suggest that discovered differences in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostic of primary cancerous growth as well as in estimation of effectiveness specific cancer treatment. In clinical studies (1495 of patients with cancer of mammary gland, lungs, prostate, ovaries, bladder or digestive tract) we shown that in biological fluids and tumors of cancer patients significant changes of physiological concentrations of amino acids real or indirectly regulate processes of the antitumor response, oncogenesis, immunogenesis and apoptosis. Our strategy of application of amino acids as medicinal preparations includes a directional effect on the functional and metabolic relationships, which change in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application in oncology of their regulatory effects discussed.
Keywords
Free amino acids; Regulatory effects; Oncology
Cite this paper
Karavay A., Karavay P., Kaliada T., Nefyodov L.,
METABOLIC COMFORT IN ONCOLOGY AND FREE AMINO ACIDS: PERSPECTIVES FOR THE USE OF THEIR REGULATORY ACTIONS IN PHYSIOLOGICAL CONCENTRATIONS
, SCIREA Journal of Pharmacy.
Volume 1, Issue 1, October 2016 | PP. 1-7.
References
[ 1 ] | Nefyodov L. Taurine (biochemistry, pharmacology, medical application) Grodno RIPH. - 1999.- 145 p. |
[ 2 ] | Amino Acids And Their Derivatives (chemistry, biochemistry, pharmacology, medicine) /ed. L.Nefyodov // Proc of Internat. Symp; Grodno. – 1996. - 125 p. |
[ 3 ] | Nefyodov, L.I., Karavay, P.A., Karavay, N.L. Regulatory action of free amino acids and development on the basis of highly of substances infusion solutions with pathogenetic deterministic composition. Laboratory diagnosis Eastern Europe. – 2014.- V.3.- p.111-115. |
[ 4 ] | Holden, J.T. Amino Acid Pools. Elsevier, Amsterdam – 1962. - 815 p. |
[ 5 ] | Lubec, C. Amino Acids (Chemistry, Biology, Medicine) Escom New York – 1990.- 1196 p. |
[ 6 ] | Nefyodov, L.I. The results of biochemical research and development of nitrogen-containing compounds of natural origin: methodology of exploitation of biological properties as universal natural regulators of metabolism and drugs. – 2010.- http://www.nil.grsu.by/index.php?page=index. |
[ 7 ] | Nefyodov LI. et al. Amino acids and their derivatives in tumour tissue from patients with breast cancer treated with Ukrain. Part VI. Drugs Exp Clin Res. -1996. V.22, №3-5.-p.155-157. |
[ 8 ] | Nefyodov LI.et al. Amino acids and their derivatives in blood plasma of patients with breast cancer treated with Ukrain. Part V. Drugs Exp Clin Res. -1996. –V.22,V.3-5.-p.159-61. |
[ 9 ] | Biological activity and transport of drugs / ed. L. Nefyodov // Proc of Internat. Symp.; Grodno. – 1999. – 189 p. |
[ 10 ] | VI Ordinary General Assembly Society of Biochemistry of Belarus / ed. L. Nefyodov // Proc of Internat. Symp;. Grodno. – 2000. – 225 p. |
[ 11 ] | Amino acids and their derivatives in biology and medicine / ed. L. Nefyodov // Proc of Internat. Symp;. – Grodno. – 2001. – 124 p. |
[ 12 ] | Nefyodov, L.I. Target - oriented regulation of metabolic equilibrium by amino acids and strategy of their application as drugs with directional effects /L.I. Nefyodov // XXXVII Zjazd Polskiego towarzystwa biochemicznego, Torun.- 10-14 IX.- 2001.- p.327 |
[ 13 ] | Ihata, Y., Miyagi, E., Numazaki, R. Amino acid profile index for early detection of endometrial cancer: verification as a novel diagnostic marker. – 2013.- Int. J. Clin. Oncol. V.19, №3.- p.364-372. |
[ 14 ] | Fafournoux, P., Bruhat, A., Jousse, C. Amino acid regulation of gene expression. – 2000.- BioChem. J. - V.351.- №1.- p.1–12. |
[ 15 ] | Meijer, A. Amino acids as regulators and components of nonproteinogenic pathways. – 2003.- J. Nutr. V6.- №1.- p.2057S-2062S. |
[ 16 ] | Bruhat, A., Cherasse, Y., Chaveroux, C., et al. Amino acids as reg- ulators of gene expression in mammals: molecular mechanisms. - 2009.- Biofactors.- V35.- №3.- p.249-257. |
[ 17 ] | Ananieva E. Targeting amino acid metabolism in cancer growth and anti-tumor immune response. - 2015.- World J Biol Chem. – V.6.-V4.- 281–289. doi: 10.4331/wjbc.v6.i4.281. |
[ 18 ] | Hong Ma. Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy. – 2014.- World J Gastroenterol. – V.20.- №26.- p.8653–8659. doi: 10.3748/wjg.v20.i26.8653 |
[ 19 ] | Nefyodov L., Karavay P., Karavay N. Creation of Infusion Solutions with Pathogenetically Deterministic Com¬position on the Basis of Regulatory Actions of Free Amino Acids and their Derivatives.- J. Res. Development. – 2015.-V.3.- № 1;http://www.omicsonline.com/open-ccess/dx.doi.org/10.4172/jrd.1000122.php?aid=55625 |
[ 20 ] | Karavay P., Nefyodov L., Karavay N. Perspective for the Use of Regulatory Effects of Free Amino Acids in the Creation on their Basis of Infusion Solutions .- Academia Journal of Scientific Research.- 2015.-V.3.-V3:http:// doi:10.15413/ajsr.2015.0139. ISSN2315-7712. |