Research on the mechanism and pharmacological effects of Sophora alopecuroides L based on the Network and Data Mining

Author(s)

Abstract
In order to investigate the preliminary mechanism and pharmacological effects of the Sophora alopecuroides L, the data mining and network pharmacology were applied. The regularation of Sophora alopecuroides L by the Ancient and Modern Medical Records Cloud Platform, the molecular and structural of activity ingredient in Sophora alopecuroides L were gained by herb and the Internet of chemical, the targets of mouse were recevied by the analyze of BATMAN-TCA, Uniprot, Metascape. The data mining manifest demonstrated it was effective for both skin sores and diarrhea, the targets of the two diseases were exported from the disease database such as Genecards, String, Uniprot and Metascape. The relationship between the diseases and medicine were gained by importing the gating targets in veen Bioinformatics and Cytoscape Networks. The results showed that the therapeutic activity of Sophora alopecuroides L Centered on 11 active components such as oxymatrine, matrine, aloperine operated on key targets including TP53COR1, IL-6, TNF-α. There were respectively 21 and 30 common targets between the skin sores, diarrhea and Sophora alopecuroides L. The results indicated that the Sophora alopecuroides L can cure the skin sores and diarrhea through PI3K-Akt, JAK-STAT and the action of phosphorylation in protein by the activity compounds of oxymatrine, matrine, aloperine alkaloid.

Keywords
Sophora alopecuroides L; network pharmacology; data mining; skin sores; diarrhea; activity ingredients

Cite this paper
Chuan Yu, Mingyue Deng, Jianxing Cai, Zhihui Hao, Research on the mechanism and pharmacological effects of Sophora alopecuroides L based on the Network and Data Mining , SCIREA Journal of Animal Husbandry and Veterinary Medicine. Volume 7, Issue 1, February 2025 | PP. 1-14. 10.54647/ahvm230090

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